Physicians with Ascension Saint Thomas are warning on Apr. 9 that more young adults in Middle Tennessee and across the United States are being diagnosed with colorectal cancer, often without knowing they are at risk.
Colorectal cancer has become the deadliest cancer for Americans under 50, according to research published in JAMA. Recent data from the American Cancer Society shows nearly half of new cases occur in adults younger than 65, and one in five is diagnosed before age 55. Researchers have found that people born in 1990 face double the risk of colon cancer and four times the risk of rectal cancer compared to those born in 1950.
In Tennessee, about 3,500 people receive a colorectal cancer diagnosis each year, making it one of the most common cancers statewide. Many cases are detected at a later stage.
“Colorectal cancer is the fastest growing cancer in people under 50,” said Dr. Brett Inglis, a gastroenterologist with Ascension Saint Thomas. “We are unfortunately seeing this cancer even in 35 year olds. That was uncommon a decade ago. The reason for this sudden rise is not fully understood, and there are many ongoing investigations to find the cause.”
Inglis said several factors may contribute to increasing rates among younger adults including smoking, diet, lifestyle changes, obesity and differences in gut bacteria.
“Colorectal cancer screening rates vary by state, reaching only two thirds of the population nationally,” Inglis said. “The best test is the one that gets done. People should talk with their primary care doctor about getting screened, as colorectal cancer is the most preventable cancer.”
Doctors say early detection through screenings such as colonoscopies or at-home stool tests can greatly improve survival chances if colorectal cancer develops. Warning signs include changes in bowel habits, blood in stool, persistent abdominal pain, unexplained weight loss and fatigue.
“This cancer is very preventable and should not be the second leading cause of cancer death in our nation,” Inglis said. “Early detection can save lives.”
The U.S. Preventive Services Task Force recommends average-risk adults begin screening at age 45; those with family history or other risks may need earlier checks every five years.
Ascension Saint Thomas urges residents to discuss their personal risk factors and screening options with their doctors.

